Classical and desmosomal cadherins at a glance.
نویسندگان
چکیده
Masataka Saito*, Dana K. Tucker*, Drew Kohlhorst, Carien M. Niessen and Andrew P. Kowalczyk Departments of Cell Biology, Dermatology and the Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA Department of Dermatology, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), Center for Molecular Medicine Cologne, University of Cologne, Cologne D-50931, Germany
منابع مشابه
Plakoglobin domains that define its association with the desmosomal cadherins and the classical cadherins: identification of unique and shared domains.
Two cell-cell junctions, the adherens junction and the desmosome, are prominent in epithelial cells. These junctions are composed of transmembrane cadherins which interact with cytoplasmic proteins that serve to link the cadherin to the cytoskeleton. One component of both adherens junctions and desmosomes is plakoglobin. In the adherens junction plakoglobin interacts with both the classical cad...
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Classical cadherins mediate specific adhesion at intercellular adherens junctions. Interactions between cadherin ectodomains from apposed cells mediate cell-cell contact, whereas the intracellular region functionally links cadherins to the underlying cytoskeleton. Structural, biophysical, and biochemical studies have provided important insights into the mechanism and specificity of cell-cell ad...
متن کاملCoexpression of both types of desmosomal cadherin and plakoglobin confers strong intercellular adhesion.
Desmosomes are unique intercellular junctions in that they invariably contain two types of transmembrane cadherin molecule, desmocollins and desmogleins. In addition they possess a distinct cytoplasmic plaque structure containing a few major proteins including desmoplakins and the armadillo family member plakoglobin. Desmosomal cadherins are putative cell-cell adhesion molecules and we have tes...
متن کاملMolecular interactions between desmosomal cadherins.
Desmocollins (Dscs) and desmogleins (Dsgs) are cell-adhesion molecules involved in the formation of desmosome cell-cell junctions and share structural similarities to classical cadherins such as E-cadherin. In order to identify and provide quantitative information on the types of protein-protein interactions displayed by the type 2 isoforms and investigate the role of Ca(2+) in this process, we...
متن کاملThe cadherin superfamily.
The poster provides an overview of the cadherin superfamily, depicting representative molecules for several subfamilies, and displaying the plethora of molecular arrangements characteristic of these molecules (see Commentary by Angst, Marcozzi and Magee on p. 629). Classical cadherins form lateral dimers and typically mediate homophilic adhesion between neighbouring cells and linkage to the act...
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عنوان ژورنال:
- Journal of cell science
دوره 125 Pt 11 شماره
صفحات -
تاریخ انتشار 2012